ABSTRACT
Objective To analyze the Epstein-Barr virus(EBV) infection status in children .Methods The EBV infection related antibody data of the children patients in our center during 2013 were collected and performed the statistical analysis on the age ,dis-ease type and month distribution .Results Totally 7 582 children cases were detected .The total infection rate of EBVCA-IgM was 16 .97% .The positive rates of specific EBVCA-IgM in different age stages were 15 .92% in 0 - <3 years old ,22 .53% in 3 - <6 years old ,16 .69% in 6- <10 years old and 8 .30% in more than 10 years old;in EBV infection cases ,most of them were infections mononucleosis ,followed by respiratory tract infection ;March and September had the highest EBV infection rate .The positive rates of series antibodies detection of EBV were 19 .11% for EBVCA-IgM ,61 .57% for EBVCA-IgG ,53 .76% for EBNA-1-IgG and 9 .50% for EBVEA-IgG ,the proportion of the combination of positive EBVCA-IgG and positive EBNA-1-IgG was highest ,account-ing for 39 .57% .Conclusion EBV is an important infectious pathogen in children infection ;39 .57% of children are once infected by EBV in the past ;with the age increase ,the EBV infection proportion will be decreased .
ABSTRACT
Objective To determine the viral etiology and its epidemic features of community-acquired pneumonia ( CAP) among pediatric inpatients in Guangzhou.Methods A total of 1 539 children with CAP admitted in Guangzhou Women and Children’ s Medical Center during June 2012 and June 2013 were enrolled in the study.Throat swab specimens were collected, and fluorescence quantitative polymerase chain reaction ( FQ-PCR) was performed to detect 11 respiratory pathogens.SPSS 17.0 was used for data processing, and χ2 test was performed to compare the infection rates among different groups.Results Among 1 539 patients, 550 cases (35.7%) were infected with at least one pathogen, and 101 (6.6%) were infected with two or more pathogens.The most popular viral etiologies were respiratory syncytial virus (RSV) (102, 6.6%), rhinovirus (RHV)(101, 6.6%), adenovirus (ADV) (78, 5.1%), influenza virus A (IVA) (78, 5.1%) and bocavirus (HBOV) (74, 4.8%).RSV infection often occurred in children with age≤3 years, while ADV or IVA infection often occurred in those with age >3 years.RSV infection rate peaked in winter and spring, IVA infection rate peaked in spring and summer, while ADV and HBOV infection rates peaked in summer.The rate of multiple infections in critically ill children (22/135, 16.3%) was significantly higher than that in other CAP patients (79/1 404,5.6%,χ2 =116.049, P<0.01).Conclusions Viral infection is common in pediatric inpatients with CAP, and RSV infection is the most popular.Multiple infections are more often to cause critical conditions.